Terbinafine vs Clotrimazole: Know the Differences

Terbinafine vs Clotrimazole: Terbinafine and Clotrimazole are both antifungal medicinal drugs generally used to deal with ringworm, a fungal infection of the skin. While Clotrimazole disrupts fungal mobile membranes to inhibit boom, Terbinafine works via blockading an enzyme essential for fungal cell membrane synthesis, main to cell loss of life. Clotrimazole, available over-the-counter, is commonly used for moderate instances, whereas Terbinafine, available OTC or via prescription, is reserved for greater intense or resistant infections. Treatment preference relies upon elements together with contamination severity and patient history, necessitating consultation with a healthcare expert for proper prognosis and remedy.

Difference between Terbinafine and Clotrimazole

Terbinafine and Clotrimazole are antifungal medications used for ringworms; Clotrimazole disrupts fungal cellular membranes, while Terbinafine inhibits enzyme characteristics. The table below provides the differences between Terbinafine and Clotrimazole.




Mechanism of Action

Inhibits fungal growth

Disrupts fungal cell membranes

Forms Available

Oral tablets, creams, topical solutions

Creams, lotions, powders


Oral or topical application

Topical application only

Treatment Area

Can be used for skin, scalp, and nails

Primarily used for skin and vaginal infections

Prescription Requirement

Both over-the-counter and prescription

Both over-the-counter and prescription

Dosage Form

Tablets: 250 mg

Creams: 1% to 2%

Frequency of Use

Once daily for oral tablets; applied topically as directed

Applied topically multiple times a day as directed

Common Side Effects

Gastrointestinal upset, headache, liver abnormalities

Skin irritation, itching, allergic reactions

Treatment Duration

Typically several weeks

Typically several weeks


Effective for severe or widespread infections

Effective for mild to moderate infections

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What is Terbinafine?

Terbinafine is an antifungal medicinal drug generally used to treat ringworm infections. It works through inhibiting the increase of the fungus answerable for the infection, in the end leading to its eradication. Terbinafine is available in diverse bureaucracy, consisting of creams, gels, and oral pills, and is regularly prescribed based on the severity and region of the ringworm contamination.

Features of Terbinafine

  • Broad Spectrum: Terbinafine is effective against a extensive variety of fungal infections, inclusive of dermatophytes (along with Trichophyton species, Microsporum species, and Epidermophyton species) which generally cause situations like athlete's foot, ringworm, and jock itch.
  • Fungicidal Action: Unlike some antifungal medications that simply inhibit the increase of fungi (fungistatic), Terbinafine is fungicidal. It actively kills the fungi accountable for infections as opposed to just stopping their growth.
  • Oral and Topical Forms: Terbinafine is to be had in both oral and topical paperwork, imparting flexibility in remedy options depending on the severity and place of the contamination. Oral Terbinafine is frequently prescribed for nail infections and more extreme instances of pores and skin infections, even as topical formulations are appropriate for milder pores and skin infections.
  • Long Duration of Action: Terbinafine has an extended duration of action, bearing in mind as soon as each day dosing in oral formulations. This can enhance patient compliance with the remedy routine.

What is Clotrimazole?

Clotrimazole is an antifungal remedy normally used to deal with fungal infections, such as ringworm. Ringworm, notwithstanding its call, isn't always resulting from a bug however as a substitute via a fungus. It's a contagious fungal contamination that can affect the pores and skin, scalp, or nails, causing red, itchy, and ring-fashioned rashes.

Features of Clotrimazole

  • Antifungal Properties: Clotrimazole is basically used as an antifungal remedy. It inhibits the increase of various fungi through disrupting their mobile membranes, ultimately leading to their dying.
  • Broad Spectrum: Clotrimazole reveals activity against a extensive range of fungi, including dermatophytes, yeasts, and molds.
  • Topical Formulations: It is available in diverse topical formulations, together with lotions, creams, powders, and solutions, which are carried out at once to the affected pores and skin or mucous membranes.
  • Over-the-Counter Availability: Many Clotrimazole formulations are available over-the-counter, making them without problems available for self-remedy of fungal infections like athlete's foot, jock itch, and yeast infections.
  • Ease of Use: Clotrimazole creams and answers are commonly easy to apply, allowing for handy remedy of affected regions.

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Similarities between Terbinafine and Clotrimazole

  • Antifungal Activity: Both Terbinafine and Clotrimazole exhibit antifungal residences, successfully concentrated on and killing the fungi responsible for inflicting ringworm infections. They disrupt fungal cell membranes, main to fungal cell demise.
  • Broad Spectrum: Both medicinal drugs have extensive-spectrum pastime in opposition to more than a few fungi, inclusive of dermatophytes like Trichophyton, Microsporum, and Epidermophyton species, which commonly cause ringworm.
  • Topical Formulations: Both Terbinafine and Clotrimazole are to be had in diverse topical formulations, inclusive of lotions, lotions, powders, and answers, bearing in mind direct utility to the affected skin.

When identifying between Terbinafine and Clotrimazole for treating ringworm, factors including the severity of the contamination, the area of the contamination, and man or woman affected person factors (consisting of allergies or clinical history) ought to be considered. In slight instances, Clotrimazole can be enough, whilst greater extreme or chronic infections may require using Terbinafine. It's continually satisfactory to consult with a healthcare professional for correct analysis and remedy pointers.

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What is ringworm and how is it dealt with?

Ringworm is a fungal contamination that impacts the pores and skin, scalp, or nails, causing pink, itchy, and now and again round rashes. It's treated with antifungal medicines.

What is Terbinafine and how does it work?

Terbinafine is an antifungal medicinal drug that works through inhibiting the growth of fungi. It's available in oral pills, lotions, and topical solutions.

What is Clotrimazole and the way does it work?

Clotrimazole is an antifungal medicine that disrupts the cell membranes of fungi. It comes in diverse forms including creams, lotions, and powders for topical utility.

Which one is greater powerful for treating ringworm, Terbinafine, or Clotrimazole?

Both Terbinafine and Clotrimazole are effective antifungal medications for treating ringworm. The preference among them may additionally rely upon elements inclusive of the severity of the infection, the patient's desire, and any underlying health situations.

How is Terbinafine used to deal with ringworm?

Terbinafine may be used orally in the shape of pills for excessive or widespread instances of ringworm. It's usually taken once day by day for some weeks beneath the supervision of a healthcare professional.

How is Clotrimazole used to treat ringworm?

Clotrimazole is commonly implemented topically to the affected location a couple of times an afternoon for several weeks. It's available in numerous formulations along with lotions, creams, and powders.