Difference between lupus arthritis and rheumatoid arthritis

Differences Between Rheumatoid Arthritis and Rheumatic Fever: Rheumatoid arthritis (RA) and rheumatic fever (RF) are both inflammatory conditions that affect the body's joints and connective tissues. While they share some similarities in symptoms and manifestations, they are distinct diseases with different causes, risk factors, and treatment approaches. Understanding the differences between RA and RF is essential for accurate diagnosis and appropriate management.

Differences Between Rheumatoid Arthritis and Rheumatic Fever: 

While rheumatoid arthritis (RA) and rheumatic fever (RF) share some similarities in their inflammatory nature and systemic manifestations, they are distinct diseases with different etiologies, age of onset, joint involvement patterns, and long-term complications. Proper diagnosis and management tailored to each condition's unique characteristics are crucial for optimizing patient outcomes and improving quality of life. The differences are discussed below.


Rheumatoid Arthritis (RA)

Rheumatic Fever (RF)


Autoimmune disease

Complication of untreated streptococcal throat infection

Age of Onset

Typically in adulthood

Primarily affects children and adolescents

Joint Involvement

Symmetrical, small joints of hands and feet

Asymmetrical, larger joints such as knees, elbows, and ankles

Associated Organ Involvement

Systemic involvement including lungs, heart, and eyes

Primarily affects heart, joints, skin, and central nervous system

Diagnostic Markers

Positive rheumatoid factor (RF) and anti-CCP antibodies

Evidence of preceding streptococcal infection, Jones criteria

Treatment Approach

Disease-modifying antirheumatic drugs (DMARDs), biologics

Antibiotics to treat streptococcal infection, anti-inflammatory agents, prophylactic antibiotics for recurrent streptococcal infections

Long-Term Complications

Joint damage, disability, increased cardiovascular risk

Rheumatic heart disease, valvular heart damage


No specific prevention strategies

Prompt treatment of streptococcal infections with antibiotics

What is Rheumatoid Arthritis (RA)?

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation of the synovial membrane, which lines the joints. In RA, the immune system mistakenly attacks the body's own tissues, primarily targeting the joints, leading to pain, swelling, stiffness, and progressive joint damage. RA commonly affects the small joints of the hands and feet symmetrically but can also involve other joints and organs, such as the lungs and heart.

Key Features of Rheumatoid Arthritis

  1. Autoimmune Disease: RA is an autoimmune disease where the body's immune system attacks its own tissues, primarily affecting the joints.
  2. Symmetrical Joint Involvement: RA typically affects joints on both sides of the body symmetrically.
  3. Chronic Inflammation: Persistent inflammation in the synovial membrane leads to joint pain, swelling, and stiffness.
  4. Systemic Manifestations: RA can also involve other organs and systems in the body, such as the skin, eyes, lungs, and heart.
  5. Progressive Joint Damage: Without proper treatment, RA can cause irreversible joint damage, deformities, and disability.
  6. Rheumatoid Factor and Anti-CCP Antibodies: Blood tests for rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibodies are often positive in RA patients.

What is Rheumatic Fever (RF)?

Rheumatic fever (RF) is an inflammatory condition that can develop as a complication of untreated or inadequately treated streptococcal throat infection, particularly with group A Streptococcus bacteria. RF primarily affects the heart, joints, skin, and central nervous system. It typically occurs in children and adolescents, weeks after a streptococcal infection, such as strep throat or scarlet fever. RF can cause damage to the heart valves, leading to rheumatic heart disease, a chronic condition with long-term implications for heart health.

Key Features of Rheumatic Fever

  1. Post-Streptococcal Complication: RF usually develops following a streptococcal throat infection, with symptoms appearing weeks after the initial infection.
  2. Acute Inflammatory Response: RF is characterized by inflammation of the heart (carditis), joints (arthritis), skin (erythema marginatum), and central nervous system (Sydenham's chorea).
  3. Cardiac Involvement: Rheumatic heart disease, a consequence of RF, can lead to damage to the heart valves, causing valve regurgitation or stenosis.
  4. Risk Factors: RF primarily affects children and adolescents, particularly in socioeconomically disadvantaged populations with limited access to healthcare.
  5. Preventable with Antibiotics: Prompt treatment of streptococcal infections with antibiotics can prevent the development of RF and its complications.
  6. Jones Criteria: Diagnosis of RF is based on the revised Jones criteria, which include clinical manifestations and evidence of preceding streptococcal infection.

Similarities Between Rheumatoid Arthritis and Rheumatic Fever

  1. Inflammatory Conditions: Both RA and RF involve inflammation of the joints and other tissues in the body.
  2. Autoimmune Component: While RF is triggered by a bacterial infection, both diseases involve immune-mediated damage to the body's tissues.
  3. Systemic Manifestations: Both diseases can affect multiple organs and systems beyond the joints.
  4. Treatment Approach: Treatment aims to reduce inflammation, alleviate symptoms, and prevent long-term complications in both conditions.
  5. Chronic Nature: Both RA and RF can have long-term implications for health and may require ongoing management and monitoring.
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1. Can Rheumatoid Arthritis and Rheumatic Fever Coexist?

While it's rare for RA and RF to occur simultaneously, individuals with a history of RF may develop RA later in life due to unrelated autoimmune mechanisms.

2. What Are the Cardiac Complications of Rheumatoid Arthritis?

RA is associated with an increased risk of cardiovascular disease, including coronary artery disease, heart failure, and myocarditis.

3. Is Rheumatic Fever Contagious?

Rheumatic fever itself is not contagious, but the streptococcal infections that can lead to RF can be transmitted from person to person through respiratory droplets.

4. Can Rheumatic Fever Be Prevented?

Prompt treatment of streptococcal throat infections with antibiotics can prevent the development of RF and its complications.

5. How Is Rheumatic Fever Diagnosed?

The diagnosis of RF is based on clinical manifestations and evidence of preceding streptococcal infection, according to the Jones criteria.

6. Are There Any Dietary Recommendations for Managing Rheumatoid Arthritis and Rheumatic Fever?

While there's no specific diet to cure these conditions, a balanced diet rich in fruits, vegetables, whole grains, and omega-3 fatty acids may help reduce inflammation and support overall health. Some individuals may find relief by avoiding certain foods that trigger inflammation, such as processed foods, refined sugars, and saturated fats.

7. Can Exercise Help Manage Symptoms of Rheumatoid Arthritis and Rheumatic Fever?

Regular exercise can be beneficial for individuals with RA and RF by improving joint flexibility, muscle strength, and overall mobility. Low-impact activities such as swimming, walking, and yoga can help manage symptoms without exacerbating joint pain or inflammation. It's essential to consult with a healthcare provider or a physical therapist to develop an exercise program tailored to individual needs and limitations.

8. What Role Does Stress Play in Rheumatoid Arthritis and Rheumatic Fever?

While stress itself doesn't cause RA or RF, it can exacerbate symptoms and trigger flare-ups by activating the body's inflammatory response. Practicing stress-reduction techniques such as mindfulness, meditation, deep breathing exercises, and relaxation techniques may help manage symptoms and improve overall well-being.

9. Can Rheumatoid Arthritis and Rheumatic Fever Affect Fertility and Pregnancy?

Both RA and RF can potentially affect fertility and pregnancy outcomes. Women with RA may experience challenges conceiving due to the disease itself or medications used to manage symptoms. Additionally, uncontrolled inflammation in RA or complications from RF, such as heart valve damage, can pose risks during pregnancy. It's crucial for individuals with these conditions to work closely with their healthcare providers to optimize disease management before and during pregnancy.

10. Is Genetic Predisposition a Risk Factor for Rheumatoid Arthritis and Rheumatic Fever?

While genetics play a role in the development of both RA and RF, they are multifactorial diseases influenced by a combination of genetic, environmental, and immunological factors. Individuals with a family history of RA or RF may have an increased risk of developing these conditions, but genetic predisposition alone is not sufficient to cause the diseases. Environmental triggers, such as infections or lifestyle factors, may also contribute to disease onset and progression.