Aplastic Anemia Vs Hemolytic Anemia: Know the Differences

blog banner
blog banner

Difference between Aplastic Anemia vs Hemolytic Anemia: Aplastic Anemia is defined by the bone marrow's inability to create adequate blood cells, resulting in a lack of red blood cells, white blood cells, and platelets. It can be inherited or acquired, and its causes might range from autoimmune diseases to exposure to chemicals. Conversely, Hemolytic Anemia is caused by the early breakdown of red blood cells, which can be brought on by intrinsic factors like genetic diseases or extrinsic factors like infections or autoimmune reactions. Hemolytic Anemia is characterized by symptoms including jaundice and an enlarged spleen as a result of accelerated red blood cell breakdown, while Aplastic Anemia is characterized by a worldwide drop in blood cell numbers. 

Difference between Aplastic Anemia and Hemolytic Anemia

Aplastic Anemia is defined by bone marrow failure, which results in insufficient blood cell formation, where as Hemolytic Anemia is defined by the early destruction of red blood cells, which causes a shortfall. The table below provides the differences between Aplastic Anemia and Hemolytic Anemia.


Aplastic Anemia

Hemolytic Anemia


Bone marrow failure to produce enough blood cells (RBCs, WBCs, platelets)

Premature destruction of red blood cells


Acquired (toxins, medications, infections, autoimmune disorders) or inherited

Intrinsic (genetic disorders like sickle cell Anemia, Thalassemia) or extrinsic (autoimmune reactions, infections, medications)


Reduced production of blood cells due to bone marrow failure

Increased destruction of red blood cells, often within the bloodstream or spleen/liver


Fatigue, weakness, shortness of breath, pale skin, rapid/irregular heartbeat, frequent infections, bleeding

Fatigue, weakness, jaundice, dark urine, enlarged spleen


Blood transfusions, mediations to stimulate blood cell production, immunosuppressive therapy, stem cell transplantation

Address underlying cause, blood transfusions, immunosuppressive therapy (in autoimmune cases), splenectomy (in certain cases)


Variable, depends on severity and response to treatment

Variable, depends on underlying cause and response to treatment

Browse The Best Scrubs Collection!

What is Aplastic Anemia?

Aplastic Anemia is a rare hematologic condition marked by insufficient production of red, white, and platelet blood cells by the bone marrow. Symptoms of this insufficiency include weakness, exhaustion, bleeding, and an increased risk of infections. It can be inherited or acquired, and its common causes include idiopathic factors, infections, autoimmune illnesses, exposure to toxins, and certain drugs. Depending on the severity and underlying reason, treatment options may include immunosuppressive treatments, blood transfusions, drugs to encourage blood cell production or stem cell transplantation.

Causes of Aplastic Anemia

  • Idiopathic Aplastic Anemia: This type of Anemia is named as such because it frequently has no known etiology.
  • Autoimmune Disorders: The immune system of the body unintentionally targets and kills the bone marrow cells that produce blood cells.
  • Toxin Exposure: Aplastic Anemia can be caused by some chemicals that harm the bone marrow, such as benzene, pesticides, and insecticides. Aplastic Anemia can also result from cancer treatments such as chemotherapy and radiation therapy.
  • Infections: Aplastic Anemia can result from the suppression of bone marrow function caused by viral infections, including hepatitis, Epstein-Barr virus (EBV), cytomegalovirus (CMV), parvovirus B19, and HIV. 
  • Hereditary Conditions: Fanconi Anemia and Dyskeratosis Congenita are two rare instances in which Aplastic Anemia can be inherited.

Symptoms of Aplastic Anemia

  • Fatigue: The sensation of extreme weakness or exhaustion, even after getting enough rest.
  • Breathlessness: As a result of the blood's reduced ability to carry oxygen due to a low red blood cell count, or Anemia.
  • Pale Skin: Pale skin is caused by a lack of red blood cells and decreased tissue oxygenation.
  • Fast Heartbeat: The body's attempt to make up for low blood oxygen levels.
  • Frequent Infections: People with leukopenia, or low white blood cell counts, may be more prone to infections.
  • Easy or Excessive Bruising: Thrombocytopenia, a low platelet count, impairs blood coagulation, which makes minor injuries more prone to prolonged bleeding or easy bruising.
  • Nosebleed: Blood clotting disorders such as thrombocytopenia can also present as bleeding gums or nosebleeds. 

What is Hemolytic Anemia?

Hemolytic Anemia is defined as the premature destruction of red blood cells (erythrocytes) in the circulation, spleen, or liver, resulting in a reduction in the amount of circulating red blood cells. Although red blood cells normally have a 120-day life lifetime, Hemolytic Anemia causes them to break down more quickly than usual.

Causes of Hemolytic Anemia

  • Autoimmune Diseases: The immune system of the body accidentally destroys its red blood cells in autoimmune Hemolytic Anemia. Numerous autoimmune conditions, including lupus, rheumatoid arthritis, and certain infections, may be the cause of this.
  • Infections: Some infections, especially those caused by specific bacteria or parasites, can cause Hemolytic Anemia by either directly harming red blood cells or by inciting the immune system to attack them. 
  • Hemoglobin Disorders: Deviations from the normal hemoglobin molecule can also result in Hemolytic Anemia. Anomalies like sickle cell disease and thalassemia cause aberrant hemoglobin synthesis, which causes red blood cells to break down too soon.
  • Medication and Toxins: Certain drugs or toxins can harm red blood cells, leading to Hemolytic Anemia. For instance, certain over-the-counter medicines, antibiotics (including penicillin), and some drugs used in chemotherapy might cause hemolysis in vulnerable people.
  • Hemolytic Disease of the newborn (HDN): This illness is brought on by the mother's antibodies attacking the fetus's or infant's red blood cells. If the mother and child have incompatible blood types, such as Rh incompatibility or ABO incompatibility, HDN may occur. 

Symptoms of Hemolytic Anemia

  • Fatigue: Because of the blood's reduced ability to carry oxygen, feeling abnormally weak or exhausted is a common symptom of Anemia, including Hemolytic Anemia.
  • Pale Skin: Hemolytic Anemia can lead to a reduction in red blood cell counts, which can cause the skin, lips, and nail beds to seem pale.
  • Breathlessness: Breathlessness can be caused by reduced oxygen transport to tissues, particularly during physical activity.
  • Fast Heartbeat: The heart may beat more quickly to make up for the blood's reduced ability to deliver oxygen.
  • Jaundice: Hemolytic Anemia can result in a build-up of the yellow pigment bilirubin, which is created when red blood cells break down. This may result in pale feces, dark urine, jaundice, or yellowing of the skin and eyes.

Shop Best Lab Coats From Here!

Similarities between Aplastic Anemia and Hemolytic Anemia

  • Anemia: Both Aplastic Anemia and Hemolytic Anemia result in a decreased number of red blood cells circulating in the bloodstream, leading to Anemia. This can cause symptoms such as fatigue, weakness, and pallor.
  • Symptoms: The symptoms of Anemia can overlap between the two conditions. Patients with both Aplastic and Hemolytic Anemia may experience fatigue, shortness of breath, rapid heart rate, and pale skin.
  • Complications: Both conditions can lead to complications related to reduced oxygen delivery to tissues. These complications may include heart problems, such as palpitations or heart murmurs, as well as symptoms related to tissue hypoxia, such as dizziness or chest pain.
  • Treatment: Although Aplastic Anemia and Hemolytic Anemia have different particular therapies, they may use similar treatment modalities. For instance, blood transfusions can be used to treat severe cases of both illnesses to raise red blood cell counts and reduce anemic symptoms. In some cases of both illnesses, immunosuppressive medication may also be utilized to control the immune system's reaction.
  • Increased Risk of Infections: Because of anomalies in the immune system, both disorders can make you more susceptible to infections. HemolyticAnemia may be linked to autoimmune diseases that impair immune function, whereas Aplastic Anemiamay result in a diminished immunological response because white blood cell synthesis is reduced.

In conclusion, even though anomalies in the synthesis or breakdown of red blood cells are shared by both Hemolytic Anemia and Aplastic Anemia, their underlying mechanisms and causes differ, resulting in unique clinical presentations and therapeutic modalities.

Order the Best Jogger Scrub From Here!

Check out More Articles
Difference Between Cartilage and Bone
Difference Between Endocrine and Exocrine Glands
Difference Between Cell Wall and Cell Membrane


What is Aplastic Anemia?

Aplastic Anemia is a rare condition in which the bone marrow is unable to generate sufficient red, white, and platelet-forming blood cells.

What causes Aplastic Anemia?

Aplastic Anemia can be caused by inherited genetic defects, certain drugs, radiation therapy, autoimmune illnesses, or exposure to chemicals. However, the precise etiology of the condition is frequently unknown.

What is Hemolytic Anemia?

Hemolytic Anemia is a disorder that is defined by the early breakdown of red blood cells. This can occur as a result of either intrinsic Hemolytic Anemia, which is caused by faults in the red blood cells themselves, or extrinsic Hemolytic Anemia, which is caused by factors outside the red blood cells.

What causes Hemolytic Anemia?

Widely differing factors can be the cause, such as autoimmune reactions, infections, poisons, drugs, sickle cell Anemia, Thalassemia, and other hereditary illnesses; or specific medical problems like lymphoma or leukemia.

What are the similarities between Aplastic Anemia and Hemolytic Anemia?

The reduced red blood cell count and function in both Hemolytic and Aplastic Anemia can result in symptoms like weakness, exhaustion, and pale skin. Furthermore, blood transfusions can be necessary for both illnesses as part of the therapy plan.

What are the differences between Aplastic Anemia and Hemolytic Anemia?

Hemolytic Anemia causes red blood cells to break down too soon, whereas Aplastic Anemia causes the bone marrow to produce fewer blood cells. Furthermore, pancytopenia, or low levels of all blood cell types, is a common presentation of Aplastic Anemia, whereas Hemolytic Anemia can cause jaundice as a result of elevated bilirubin from the breakdown of red blood cells.